Renal Excretion of N4-Acetyl Sulphanilamide and N4-Acetyl Sulphadimidine in Goats

Cloning and expression of peptide-N4-(N-acetyl-beta-D-glucosaminyl)asparagine amidase F in Escherichia coli.

The peptide-N4-(N-acetyl-beta-D-glucosaminyl) asparagine amidase F (PNGase F) gene from Flavobacterium meningosepticum was cloned into a high copy number Escherichia coli plasmid. Levels of PNGase F activity produced in cultures of the recombinant strain were up to 100-fold higher than those obtained in cultures of F. meningosepticum. The complete PNGase F gene sequence was determined. Comparis...

Pharmacokinetics of Sulfamethoxazole with its Hydroxy Metabolites and N4-Acetyl-, Nl-Glucuronide Conjugates in Healthy Human Volunteers

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Movable (n4) Configurations

An (nk) configuration is a collection of points and straight lines, usually in the Euclidean plane, so that each point lies on k lines and each line passes through k points; such a configuration will be called symmetric if it possesses non-trivial geometric symmetry. Although examples of symmetric (n3) configurations with continuous parameters are known, to this point, all known connected infin...

Formation and elimination of sulphamethoxazole hydroxylamine after oral administration of sulphamethoxazole.

The formation and elimination of sulphamethoxazole hydroxylamine in relation to the pharmacokinetics of the parent compound and its N4-acetyl metabolite were investigated in six healthy subjects after a single oral dose of 800 mg sulphamethoxazole. The apparent half-lives of sulphamethoxazole and its metabolites were approximately 10 h, indicative of formation rate-limited metabolism. The mean ...